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Unfortunately, like everything else in your house your computer can also use a good cleaning as well. A good wipe down every now and then will keep your computer in tip top running shape for years to come. For the Computer Case itself you can use a glass cleaner or a damp towel. However, for the CD ROM and other small openings it's best to use just a damp cloth or Q-tips. Also, make sure the towel is only slightly damp so no water drips onto any of parts.